PLCB1-RBL1 Fusion FISH Probe
The PLCB1-RBL1 Fusion FISH Probe is used to confirm a fusion of the PLCB1 and RBL1 genes. The fusion of the PLCB1 and RBL1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLCB1-RBL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-RERE | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-REOR | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-REGO | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-REGR | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-REAQ | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-ORRE | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-OROR | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-ORGO | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-GORE | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-GOOR | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-GOGO | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-GOGR | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-GRRE | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-GROR | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-GRGO | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-GRGR | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-AQRE | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-AQOR | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-AQGO | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-AQGR | 20 (40 μL) | 200 μL |
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| PLCB1-RBL1-20-AQAQ | 20 (40 μL) | 200 μL |
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RBL1 Gene Summary
The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: RB Transcriptional Corepressor Like 1
Chromosome: CHR20: 35626177 -35724410
Locus: 20q11.23
PLCB1 Gene Summary
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Phospholipase C Beta 1
Chromosome: CHR20: 8113295 -8865547
Locus: 20p12.3
Gene Diseases
The PLCB1 RBL1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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