PLCB1-MCM8 Fusion FISH Probe
The PLCB1-MCM8 Fusion FISH Probe is used to confirm a fusion of the PLCB1 and MCM8 genes. The fusion of the PLCB1 and MCM8 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PLCB1-MCM8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-RERE | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-REOR | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-REGO | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-REGR | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-OROR | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-GORE | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-GROR | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| PLCB1-MCM8-20-AQAQ | 20 (40 μL) | 200 μL |
|
PLCB1 Gene Summary
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Phospholipase C Beta 1
Chromosome: CHR20: 8113295 -8865547
Locus: 20p12.3
MCM8 Gene Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]
Gene Name: Minichromosome Maintenance 8 Homologous Recombination Repair Factor
Chromosome: CHR20: 5931297 -5975831
Locus: 20p12.3
Gene Diseases
The PLCB1 MCM8 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|