PLBD2-FBXO21 Fusion FISH Probe
The PLBD2-FBXO21 Fusion FISH Probe is used to confirm a fusion of the PLBD2 and FBXO21 genes. The fusion of the PLBD2 and FBXO21 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLBD2-FBXO21-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-RERE | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-REOR | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-REGO | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-REGR | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-REAQ | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-ORRE | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-OROR | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-ORGO | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-GORE | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-GOOR | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-GOGO | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-GOGR | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-GRRE | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-GROR | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-GRGO | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-GRGR | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-AQRE | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-AQOR | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-AQGO | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-AQGR | 20 (40 μL) | 200 μL |
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| PLBD2-FBXO21-20-AQAQ | 20 (40 μL) | 200 μL |
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FBXO21 Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Gene Name: F-box Protein 21
Chromosome: CHR12: 117581584 -117628300
Locus: 12q24.22
PLBD2 Gene Summary
The Phospholipase B Domain Containing 2 (PLBD2) gene is located on chr12 :113796370-113827458 at 12q24.13.
Gene Name: Phospholipase B Domain Containing 2
Chromosome: CHR12: 113796370 -113827458
Locus: 12q24.13
Gene Diseases
The PLBD2 FBXO21 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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