PLAUR-WDR45 Fusion FISH Probe
The PLAUR-WDR45 Fusion FISH Probe is used to confirm a fusion of the PLAUR and WDR45 genes. The fusion of the PLAUR and WDR45 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLAUR-WDR45-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-RERE | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-REOR | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-REGO | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-REGR | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-REAQ | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-ORRE | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-OROR | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-ORGO | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-GORE | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-GOOR | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-GOGO | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-GOGR | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-GRRE | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-GROR | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-GRGO | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-GRGR | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-AQRE | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-AQOR | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-AQGO | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-AQGR | 20 (40 μL) | 200 μL |
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| PLAUR-WDR45-20-AQAQ | 20 (40 μL) | 200 μL |
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PLAUR Gene Summary
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]
Gene Name: Plasminogen Activator, Urokinase Receptor
Chromosome: CHR19: 44150246 -44174498
Locus: 19q13.31
WDR45 Gene Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]
Gene Name: WD Repeat Domain 45
Chromosome: CHRX: 48932091 -48958059
Locus: Xp11.23
Gene Diseases
The PLAUR WDR45 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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