PLAT-SUPT16H Fusion FISH Probe
The PLAT-SUPT16H Fusion FISH Probe is used to confirm a fusion of the PLAT and SUPT16H genes. The fusion of the PLAT and SUPT16H genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLAT-SUPT16H-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-RERE | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-REOR | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-REGO | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-REGR | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-REAQ | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-ORRE | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-OROR | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-ORGO | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-GORE | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-GOOR | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-GOGO | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-GOGR | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-GRRE | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-GROR | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-GRGO | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-GRGR | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-AQRE | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-AQOR | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-AQGO | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-AQGR | 20 (40 μL) | 200 μL |
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| PLAT-SUPT16H-20-AQAQ | 20 (40 μL) | 200 μL |
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PLAT Gene Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Plasminogen Activator, Tissue Type
Chromosome: CHR8: 42032235 -42065194
Locus: 8p11.21
SUPT16H Gene Summary
Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]
Gene Name: SPT16 Homolog, Facilitates Chromatin Remodeling Subunit
Chromosome: CHR14: 21819630 -21852425
Locus: 14q11.2
Gene Diseases
The PLAT SUPT16H Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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