PLAT-C12ORF66 Fusion FISH Probe
The PLAT-C12ORF66 Fusion FISH Probe is used to confirm a fusion of the PLAT and C12ORF66 genes. The fusion of the PLAT and C12ORF66 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLAT-C12ORF66-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-RERE | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-REOR | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-REGO | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-REGR | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-REAQ | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-ORRE | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-OROR | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-ORGO | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-GORE | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-GOOR | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-GOGO | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-GOGR | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-GRRE | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-GROR | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-GRGO | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-GRGR | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-AQRE | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-AQOR | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-AQGO | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-AQGR | 20 (40 μL) | 200 μL |
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| PLAT-C12ORF66-20-AQAQ | 20 (40 μL) | 200 μL |
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PLAT Gene Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Plasminogen Activator, Tissue Type
Chromosome: CHR8: 42032235 -42065194
Locus: 8p11.21
C12orf66 Gene Summary
The Chromosome 12 Open Reading Frame 66 (C12orf66) gene is located on chr12 :64586418-64616076 at 12q14.2.
Gene Name: Chromosome 12 Open Reading Frame 66
Chromosome: CHR12: 64586418 -64616076
Locus: 12q14.2
Gene Diseases
The PLAT C12ORF66 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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