PLA2R1-ITGB6 Fusion FISH Probe
The PLA2R1-ITGB6 Fusion FISH Probe is used to confirm a fusion of the PLA2R1 and ITGB6 genes. The fusion of the PLA2R1 and ITGB6 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLA2R1-ITGB6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-RERE | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-REOR | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-REGO | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-REGR | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-REAQ | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-ORRE | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-OROR | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-ORGO | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-GORE | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-GOOR | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-GOGO | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-GOGR | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-GRRE | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-GROR | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-GRGO | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-GRGR | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-AQRE | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-AQOR | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-AQGO | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-AQGR | 20 (40 μL) | 200 μL |
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| PLA2R1-ITGB6-20-AQAQ | 20 (40 μL) | 200 μL |
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ITGB6 Gene Summary
This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: Integrin Subunit Beta 6
Chromosome: CHR2: 160958232 -161056590
Locus: 2q24.2
PLA2R1 Gene Summary
This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
Gene Name: Phospholipase A2 Receptor 1
Chromosome: CHR2: 160797259 -160919126
Locus: 2q24.2
Gene Diseases
The PLA2R1 ITGB6 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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