PLA2G2A-MBTPS1 Fusion FISH Probe
The PLA2G2A-MBTPS1 Fusion FISH Probe is used to confirm a fusion of the PLA2G2A and MBTPS1 genes. The fusion of the PLA2G2A and MBTPS1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLA2G2A-MBTPS1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-RERE | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-REOR | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-REGO | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-REGR | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-REAQ | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-ORRE | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-OROR | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-ORGO | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-GORE | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-GOOR | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-GOGO | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-GOGR | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-GRRE | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-GROR | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-GRGO | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-GRGR | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-AQRE | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-AQOR | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-AQGO | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-AQGR | 20 (40 μL) | 200 μL |
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| PLA2G2A-MBTPS1-20-AQAQ | 20 (40 μL) | 200 μL |
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PLA2G2A Gene Summary
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]
Gene Name: Phospholipase A2 Group IIA
Chromosome: CHR1: 20301923 -20306932
Locus: 1p36.13
MBTPS1 Gene Summary
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. [provided by RefSeq, Feb 2014]
Gene Name: Membrane Bound Transcription Factor Peptidase, Site 1
Chromosome: CHR16: 84087368 -84150517
Locus: 16q23.3-q24.1
Gene Diseases
The PLA2G2A MBTPS1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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