PLA2G2A-ITGA6 Fusion FISH Probe
The PLA2G2A-ITGA6 Fusion FISH Probe is used to confirm a fusion of the PLA2G2A and ITGA6 genes. The fusion of the PLA2G2A and ITGA6 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLA2G2A-ITGA6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-RERE | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-REOR | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-REGO | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-REGR | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-REAQ | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-ORRE | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-OROR | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-ORGO | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-GORE | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-GOOR | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-GOGO | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-GOGR | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-GRRE | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-GROR | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-GRGO | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-GRGR | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-AQRE | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-AQOR | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-AQGO | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-AQGR | 20 (40 μL) | 200 μL |
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| PLA2G2A-ITGA6-20-AQAQ | 20 (40 μL) | 200 μL |
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ITGA6 Gene Summary
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Gene Name: Integrin Subunit Alpha 6
Chromosome: CHR2: 173292313 -173371181
Locus: 2q31.1
PLA2G2A Gene Summary
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]
Gene Name: Phospholipase A2 Group IIA
Chromosome: CHR1: 20301923 -20306932
Locus: 1p36.13
Gene Diseases
The PLA2G2A ITGA6 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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