PKP4-PDE1A Fusion FISH Probe
The PKP4-PDE1A Fusion FISH Probe is used to confirm a fusion of the PKP4 and PDE1A genes. The fusion of the PKP4 and PDE1A genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PKP4-PDE1A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-RERE | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-REOR | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-REGO | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-REGR | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-REAQ | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-ORRE | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-OROR | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-ORGO | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-ORAQ | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-GORE | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-GOOR | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-GOGO | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-GOGR | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-GOAQ | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-GRRE | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-GROR | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-GRGO | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-GRGR | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-GRAQ | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-AQRE | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-AQOR | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-AQGO | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-AQGR | 20 (40 μL) | 200 μL |
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| PKP4-PDE1A-20-AQAQ | 20 (40 μL) | 200 μL |
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PDE1A Gene Summary
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]
Gene Name: Phosphodiesterase 1A
Chromosome: CHR2: 183007182 -183387253
Locus: 2q32.1
PKP4 Gene Summary
Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]
Gene Name: Plakophilin 4
Chromosome: CHR2: 159313475 -159537940
Locus: 2q24.1
Gene Diseases
The PKP4 PDE1A Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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