PKP3-KRT1 Fusion FISH Probe
The PKP3-KRT1 Fusion FISH Probe is used to confirm a fusion of the PKP3 and KRT1 genes. The fusion of the PKP3 and KRT1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PKP3-KRT1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-RERE | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-REOR | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-REGO | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-REGR | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-REAQ | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-ORRE | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-OROR | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-ORGO | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-GORE | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-GOOR | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-GOGO | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-GOGR | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-GRRE | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-GROR | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-GRGO | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-GRGR | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-AQRE | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-AQOR | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-AQGO | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-AQGR | 20 (40 μL) | 200 μL |
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| PKP3-KRT1-20-AQAQ | 20 (40 μL) | 200 μL |
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KRT1 Gene Summary
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Gene Name: Keratin 1
Chromosome: CHR12: 53068519 -53074191
Locus: 12q13.13
PKP3 Gene Summary
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Gene Name: Plakophilin 3
Chromosome: CHR11: 394216 -404908
Locus: 11p15.5
Gene Diseases
The PKP3 KRT1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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