PKP2-MRPS35 Fusion FISH Probe
The PKP2-MRPS35 Fusion FISH Probe is used to confirm a fusion of the PKP2 and MRPS35 genes. The fusion of the PKP2 and MRPS35 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PKP2-MRPS35-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-RERE | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-REOR | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-REGO | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-REGR | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-REAQ | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-ORRE | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-OROR | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-ORGO | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-ORAQ | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-GORE | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-GOOR | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-GOGO | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-GOGR | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-GOAQ | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-GRRE | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-GROR | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-GRGO | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-GRGR | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-GRAQ | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-AQRE | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-AQOR | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-AQGO | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-AQGR | 20 (40 μL) | 200 μL |
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| PKP2-MRPS35-20-AQAQ | 20 (40 μL) | 200 μL |
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PKP2 Gene Summary
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]
Gene Name: Plakophilin 2
Chromosome: CHR12: 32943679 -33049780
Locus: 12p11.21
MRPS35 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. [provided by RefSeq, Jul 2010]
Gene Name: Mitochondrial Ribosomal Protein S35
Chromosome: CHR12: 27863705 -27909237
Locus: 12p11.22
Gene Diseases
The PKP2 MRPS35 Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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