PKN1-LDLR Fusion FISH Probe
The PKN1-LDLR Fusion FISH Probe is used to confirm a fusion of the PKN1 and LDLR genes. The fusion of the PKN1 and LDLR genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PKN1-LDLR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-RERE | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-REOR | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-REGO | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-REGR | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-REAQ | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-ORRE | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-OROR | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-ORGO | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-ORAQ | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-GORE | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-GOOR | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-GOGO | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-GOGR | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-GOAQ | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-GRRE | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-GROR | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-GRGO | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-GRGR | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-GRAQ | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-AQRE | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-AQOR | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-AQGO | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-AQGR | 20 (40 μL) | 200 μL |
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| PKN1-LDLR-20-AQAQ | 20 (40 μL) | 200 μL |
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LDLR Gene Summary
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
Gene Name: Low Density Lipoprotein Receptor
Chromosome: CHR19: 11200037 -11244505
Locus: 19p13.2
PKN1 Gene Summary
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase N1
Chromosome: CHR19: 14544165 -14582679
Locus: 19p13.12
Gene Diseases
The PKN1 LDLR Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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