PKN1-ANXA4 Fusion FISH Probe
The PKN1-ANXA4 Fusion FISH Probe is used to confirm a fusion of the PKN1 and ANXA4 genes. The fusion of the PKN1 and ANXA4 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PKN1-ANXA4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-RERE | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-REOR | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-REGO | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-REGR | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-REAQ | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-ORRE | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-OROR | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-ORGO | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-ORAQ | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-GORE | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-GOOR | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-GOGO | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-GOGR | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-GOAQ | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-GRRE | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-GROR | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-GRGO | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-GRGR | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-GRAQ | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-AQRE | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-AQOR | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-AQGO | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-AQGR | 20 (40 μL) | 200 μL |
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| PKN1-ANXA4-20-AQAQ | 20 (40 μL) | 200 μL |
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ANXA4 Gene Summary
Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]
Gene Name: Annexin A4
Chromosome: CHR2: 69969126 -70053596
Locus: 2p13.3
PKN1 Gene Summary
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase N1
Chromosome: CHR19: 14544165 -14582679
Locus: 19p13.12
Gene Diseases
The PKN1 ANXA4 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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