PITPNM2-UBE3B Fusion FISH Probe
The PITPNM2-UBE3B Fusion FISH Probe is used to confirm a fusion of the PITPNM2 and UBE3B genes. The fusion of the PITPNM2 and UBE3B genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PITPNM2-UBE3B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-RERE | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-REOR | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-REGO | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-REGR | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-REAQ | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-ORRE | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-OROR | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-ORGO | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-ORAQ | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-GORE | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-GOOR | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-GOGO | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-GOGR | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-GOAQ | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-GRRE | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-GROR | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-GRGO | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-GRGR | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-GRAQ | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-AQRE | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-AQOR | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-AQGO | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-AQGR | 20 (40 μL) | 200 μL |
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| PITPNM2-UBE3B-20-AQAQ | 20 (40 μL) | 200 μL |
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PITPNM2 Gene Summary
PITPNM2 belongs to a family of membrane-associated phosphatidylinositol transfer domain-containing proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein (Ocaka et al., 2005 [PubMed 15627748]).[supplied by OMIM, Mar 2008]
Gene Name: Phosphatidylinositol Transfer Protein Membrane Associated 2
Chromosome: CHR12: 123468026 -123594975
Locus: 12q24.31
UBE3B Gene Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2012]
Gene Name: Ubiquitin Protein Ligase E3B
Chromosome: CHR12: 109915438 -109974507
Locus: 12q24.11
Gene Diseases
The PITPNM2 UBE3B Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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