PIR-TMEM27 Fusion FISH Probe
The PIR-TMEM27 Fusion FISH Probe is used to confirm a fusion of the PIR and TMEM27 genes. The fusion of the PIR and TMEM27 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PIR-TMEM27-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-RERE | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-REOR | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-REGO | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-REGR | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-REAQ | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-ORRE | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-OROR | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-ORGO | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-ORAQ | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-GORE | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-GOOR | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-GOGO | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-GOGR | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-GOAQ | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-GRRE | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-GROR | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-GRGO | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-GRGR | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-GRAQ | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-AQRE | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-AQOR | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-AQGO | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-AQGR | 20 (40 μL) | 200 μL |
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| PIR-TMEM27-20-AQAQ | 20 (40 μL) | 200 μL |
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PIR Gene Summary
This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Gene Name: Pirin
Chromosome: CHRX: 15402923 -15511711
Locus: Xp22.2
TMEM27 Gene Summary
This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. [provided by RefSeq, Jun 2013]
Gene Name: Transmembrane Protein 27
Chromosome: CHRX: 15645440 -15683154
Locus: Xp22.2
Gene Diseases
The PIR TMEM27 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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