PILRB-MAGI2 Fusion FISH Probe
The PILRB-MAGI2 Fusion FISH Probe is used to confirm a fusion of the PILRB and MAGI2 genes. The fusion of the PILRB and MAGI2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PILRB-MAGI2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-RERE | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-REOR | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-REGO | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-REGR | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-REAQ | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-ORRE | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-OROR | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-ORGO | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-GORE | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-GOOR | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-GOGO | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-GOGR | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-GRRE | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-GROR | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-GRGO | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-GRGR | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-AQRE | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-AQOR | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-AQGO | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-AQGR | 20 (40 μL) | 200 μL |
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| PILRB-MAGI2-20-AQAQ | 20 (40 μL) | 200 μL |
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MAGI2 Gene Summary
The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008]
Gene Name: Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 2
Chromosome: CHR7: 77646373 -79082890
Locus: 7q21.11
PILRB Gene Summary
The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013]
Gene Name: Paired Immunoglobin-like Type 2 Receptor Beta
Chromosome: CHR7: 99933687 -99965454
Locus: 7q22.1
Gene Diseases
The PILRB MAGI2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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