PIKFYVE-ZNF124 Fusion FISH Probe
The PIKFYVE-ZNF124 Fusion FISH Probe is used to confirm a fusion of the PIKFYVE and ZNF124 genes. The fusion of the PIKFYVE and ZNF124 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PIKFYVE-ZNF124-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-RERE | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-REOR | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-REGO | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-REGR | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-OROR | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-GORE | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-GROR | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| PIKFYVE-ZNF124-20-AQAQ | 20 (40 μL) | 200 μL |
|
ZNF124 Gene Summary
This gene encodes a protein with an amino-terminal KRAB-A box and multiple repeated Kruppel-type (C2H2) zinc finger motifs at its carboxy terminus. The encoded protein may function as a transcription factor. Expression of this gene is increased after vascular endothelial growth factor (VEGF) stimulation in human leukemia cell lines and results in inhibition of apoptotic cell death induced by irradiation or exposure to etoposide. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2014]
Gene Name: Zinc Finger Protein 124
Chromosome: CHR1: 247285276 -247335318
Locus: 1q44
PIKFYVE Gene Summary
Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
Gene Name: Phosphoinositide Kinase, FYVE-type Zinc Finger Containing
Chromosome: CHR2: 209130990 -209223475
Locus: 2q34
Gene Diseases
The PIKFYVE ZNF124 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|