PIK3R1-MRPL42 Fusion FISH Probe
The PIK3R1-MRPL42 Fusion FISH Probe is used to confirm a fusion of the PIK3R1 and MRPL42 genes. The fusion of the PIK3R1 and MRPL42 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PIK3R1-MRPL42-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-RERE | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-REOR | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-REGO | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-REGR | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-REAQ | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-ORRE | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-OROR | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-ORGO | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-ORAQ | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-GORE | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-GOOR | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-GOGO | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-GOGR | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-GOAQ | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-GRRE | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-GROR | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-GRGO | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-GRGR | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-GRAQ | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-AQRE | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-AQOR | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-AQGO | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-AQGR | 20 (40 μL) | 200 μL |
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| PIK3R1-MRPL42-20-AQAQ | 20 (40 μL) | 200 μL |
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PIK3R1 Gene Summary
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Gene Name: Phosphoinositide-3-kinase Regulatory Subunit 1
Chromosome: CHR5: 67511583 -67597649
Locus: 5q13.1
MRPL42 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein identified as belonging to both the 28S and the 39S subunits. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 4q, 6p, 6q, 7p, and 15q. [provided by RefSeq, May 2011]
Gene Name: Mitochondrial Ribosomal Protein L42
Chromosome: CHR12: 93861265 -93897548
Locus: 12q22
Gene Diseases
The PIK3R1 MRPL42 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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