PIK3CB-KCNAB1 Fusion FISH Probe
The PIK3CB-KCNAB1 Fusion FISH Probe is used to confirm a fusion of the PIK3CB and KCNAB1 genes. The fusion of the PIK3CB and KCNAB1 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PIK3CB-KCNAB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-RERE | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-REOR | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-REGO | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-REGR | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-REAQ | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-ORRE | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-OROR | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-ORGO | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-GORE | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-GOOR | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-GOGO | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-GOGR | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-GRRE | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-GROR | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-GRGO | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-GRGR | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-AQRE | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-AQOR | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-AQGO | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-AQGR | 20 (40 μL) | 200 μL |
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| PIK3CB-KCNAB1-20-AQAQ | 20 (40 μL) | 200 μL |
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PIK3CB Gene Summary
This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Gene Name: Phosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit Beta
Chromosome: CHR3: 138374230 -138478185
Locus: 3q22.3
KCNAB1 Gene Summary
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes distinct isoforms which are encoded by alternatively spliced transcript variants of this gene. Some of these isoforms are beta subunits, which form heteromultimeric complexes with alpha subunits and modulate the activity of the pore-forming alpha subunits. [provided by RefSeq, Apr 2015]
Gene Name: Potassium Voltage-gated Channel Subfamily A Member Regulatory Beta Subunit 1
Chromosome: CHR3: 155838336 -156256927
Locus: 3q25.31
Gene Diseases
The PIK3CB KCNAB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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