PIK3CB-GRM7 Fusion FISH Probe
The PIK3CB-GRM7 Fusion FISH Probe is used to confirm a fusion of the PIK3CB and GRM7 genes. The fusion of the PIK3CB and GRM7 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PIK3CB-GRM7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-RERE | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-REOR | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-REGO | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-REGR | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-REAQ | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-ORRE | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-OROR | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-ORGO | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-ORAQ | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-GORE | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-GOOR | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-GOGO | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-GOGR | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-GOAQ | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-GRRE | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-GROR | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-GRGO | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-GRGR | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-GRAQ | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-AQRE | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-AQOR | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-AQGO | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-AQGR | 20 (40 μL) | 200 μL |
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| PIK3CB-GRM7-20-AQAQ | 20 (40 μL) | 200 μL |
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GRM7 Gene Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Gene Name: Glutamate Metabotropic Receptor 7
Chromosome: CHR3: 6902801 -7783218
Locus: 3p26.1
PIK3CB Gene Summary
This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Gene Name: Phosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit Beta
Chromosome: CHR3: 138374230 -138478185
Locus: 3q22.3
Gene Diseases
The PIK3CB GRM7 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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