PIK3C2G-PPFIBP1 Fusion FISH Probe
The PIK3C2G-PPFIBP1 Fusion FISH Probe is used to confirm a fusion of the PIK3C2G and PPFIBP1 genes. The fusion of the PIK3C2G and PPFIBP1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PIK3C2G-PPFIBP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-RERE | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-REOR | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-REGO | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-REGR | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-REAQ | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-ORRE | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-OROR | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-ORGO | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-GORE | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-GOOR | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-GOGO | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-GOGR | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-GRRE | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-GROR | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-GRGO | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-GRGR | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-AQRE | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-AQOR | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-AQGO | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-AQGR | 20 (40 μL) | 200 μL |
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| PIK3C2G-PPFIBP1-20-AQAQ | 20 (40 μL) | 200 μL |
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PIK3C2G Gene Summary
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Name: Phosphatidylinositol-4-phosphate 3-kinase Catalytic Subunit Type 2 Gamma
Chromosome: CHR12: 18414473 -18801352
Locus: 12p12.3
PPFIBP1 Gene Summary
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: PPFIA Binding Protein 1
Chromosome: CHR12: 27677044 -27848497
Locus: 12p11.23-p11.22
Gene Diseases
The PIK3C2G PPFIBP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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