PICALM-MLLT10 Fusion FISH Probe
The PICALM-MLLT10 Fusion FISH Probe is used to confirm a fusion of the PICALM and MLLT10 genes. The fusion of the PICALM and MLLT10 genes has been associated with Acute Myeloid Leukemia, and Acute Myeloid Leukemia. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PICALM-MLLT10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-RERE | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-REOR | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-REGO | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-REGR | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-REAQ | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-ORRE | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-OROR | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-ORGO | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-ORAQ | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-GORE | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-GOOR | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-GOGO | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-GOGR | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-GOAQ | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-GRRE | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-GROR | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-GRGO | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-GRGR | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-GRAQ | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-AQRE | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-AQOR | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-AQGO | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-AQGR | 20 (40 μL) | 200 μL |
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| PICALM-MLLT10-20-AQAQ | 20 (40 μL) | 200 μL |
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MLLT10 Gene Summary
This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Gene Name: MLLT10, Histone Lysine Methyltransferase DOT1L Cofactor
Chromosome: CHR10: 21823100 -22032559
Locus: 10p12.31
PICALM Gene Summary
This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Gene Name: Phosphatidylinositol Binding Clathrin Assembly Protein
Chromosome: CHR11: 85668213 -85780923
Locus: 11q14.2
Gene Diseases
The PICALM MLLT10 Fusion has been associated with the following diseases:
| Disease Name |
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| Acute Myeloid Leukemia |
| Acute Myeloid Leukemia |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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