PICALM-DDX21 Fusion FISH Probe
The PICALM-DDX21 Fusion FISH Probe is used to confirm a fusion of the PICALM and DDX21 genes. The fusion of the PICALM and DDX21 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PICALM-DDX21-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-RERE | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-REOR | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-REGO | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-REGR | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-REAQ | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-ORRE | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-OROR | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-ORGO | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-ORAQ | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-GORE | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-GOOR | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-GOGO | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-GOGR | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-GOAQ | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-GRRE | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-GROR | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-GRGO | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-GRGR | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-GRAQ | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-AQRE | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-AQOR | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-AQGO | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-AQGR | 20 (40 μL) | 200 μL |
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| PICALM-DDX21-20-AQAQ | 20 (40 μL) | 200 μL |
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PICALM Gene Summary
This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Gene Name: Phosphatidylinositol Binding Clathrin Assembly Protein
Chromosome: CHR11: 85668213 -85780923
Locus: 11q14.2
DDX21 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]
Gene Name: DExD-box Helicase 21
Chromosome: CHR10: 70715891 -70744279
Locus: 10q22.1
Gene Diseases
The PICALM DDX21 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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