PIAS3-REN Fusion FISH Probe
The PIAS3-REN Fusion FISH Probe is used to confirm a fusion of the PIAS3 and REN genes. The fusion of the PIAS3 and REN genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PIAS3-REN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-RERE | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-REOR | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-REGO | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-REGR | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-REAQ | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-ORRE | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-OROR | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-ORGO | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-ORAQ | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-GORE | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-GOOR | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-GOGO | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-GOGR | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-GOAQ | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-GRRE | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-GROR | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-GRGO | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-GRGR | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-GRAQ | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-AQRE | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-AQOR | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-AQGO | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-AQGR | 20 (40 μL) | 200 μL |
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| PIAS3-REN-20-AQAQ | 20 (40 μL) | 200 μL |
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REN Gene Summary
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]
Gene Name: Renin
Chromosome: CHR1: 204123943 -204135465
Locus: 1q32.1
PIAS3 Gene Summary
This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Protein Inhibitor Of Activated STAT 3
Chromosome: CHR1: 145575987 -145586546
Locus: 1q21.1
Gene Diseases
The PIAS3 REN Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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