PIAS1-MAP2K5 Fusion FISH Probe
The PIAS1-MAP2K5 Fusion FISH Probe is used to confirm a fusion of the PIAS1 and MAP2K5 genes. The fusion of the PIAS1 and MAP2K5 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PIAS1-MAP2K5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-RERE | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-REOR | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-REGO | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-REGR | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-REAQ | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-ORRE | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-OROR | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-ORGO | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-ORAQ | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-GORE | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-GOOR | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-GOGO | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-GOGR | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-GOAQ | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-GRRE | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-GROR | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-GRGO | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-GRGR | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-GRAQ | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-AQRE | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-AQOR | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-AQGO | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-AQGR | 20 (40 μL) | 200 μL |
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| PIAS1-MAP2K5-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP2K5 Gene Summary
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]
Gene Name: Mitogen-activated Protein Kinase Kinase 5
Chromosome: CHR15: 67835020 -68099455
Locus: 15q23
PIAS1 Gene Summary
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Gene Name: Protein Inhibitor Of Activated STAT 1
Chromosome: CHR15: 68346571 -68480404
Locus: 15q23
Gene Diseases
The PIAS1 MAP2K5 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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