PI3-CLCN3 Fusion FISH Probe
The PI3-CLCN3 Fusion FISH Probe is used to confirm a fusion of the PI3 and CLCN3 genes. The fusion of the PI3 and CLCN3 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PI3-CLCN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-RERE | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-REOR | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-REGO | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-REGR | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-REAQ | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-ORRE | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-OROR | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-ORGO | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-GORE | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-GOOR | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-GOGO | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-GOGR | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-GRRE | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-GROR | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-GRGO | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-GRGR | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-AQRE | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-AQOR | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-AQGO | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-AQGR | 20 (40 μL) | 200 μL |
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| PI3-CLCN3-20-AQAQ | 20 (40 μL) | 200 μL |
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CLCN3 Gene Summary
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Chloride Voltage-gated Channel 3
Chromosome: CHR4: 170541671 -170644338
Locus: 4q33
PI3 Gene Summary
This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]
Gene Name: Peptidase Inhibitor 3
Chromosome: CHR20: 43803539 -43805185
Locus: 20q13.12
Gene Diseases
The PI3 CLCN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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