PHLPP1-WDR12 Fusion FISH Probe
The PHLPP1-WDR12 Fusion FISH Probe is used to confirm a fusion of the PHLPP1 and WDR12 genes. The fusion of the PHLPP1 and WDR12 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PHLPP1-WDR12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-RERE | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-REOR | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-REGO | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-REGR | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-OROR | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-GORE | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-GROR | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| PHLPP1-WDR12-20-AQAQ | 20 (40 μL) | 200 μL |
|
PHLPP1 Gene Summary
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]
Gene Name: PH Domain And Leucine Rich Repeat Protein Phosphatase 1
Chromosome: CHR18: 60382671 -60647666
Locus: 18q21.33
WDR12 Gene Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.[provided by RefSeq, Dec 2008]
Gene Name: WD Repeat Domain 12
Chromosome: CHR2: 203745322 -203776949
Locus: 2q33.2
Gene Diseases
The PHLPP1 WDR12 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|