PHLDB1-IL10RA Fusion FISH Probe
The PHLDB1-IL10RA Fusion FISH Probe is used to confirm a fusion of the PHLDB1 and IL10RA genes. The fusion of the PHLDB1 and IL10RA genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PHLDB1-IL10RA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-RERE | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-REOR | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-REGO | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-REGR | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-REAQ | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-ORRE | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-OROR | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-ORGO | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-ORAQ | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-GORE | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-GOOR | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-GOGO | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-GOGR | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-GOAQ | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-GRRE | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-GROR | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-GRGO | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-GRGR | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-GRAQ | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-AQRE | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-AQOR | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-AQGO | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-AQGR | 20 (40 μL) | 200 μL |
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| PHLDB1-IL10RA-20-AQAQ | 20 (40 μL) | 200 μL |
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IL10RA Gene Summary
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
Gene Name: Interleukin 10 Receptor Subunit Alpha
Chromosome: CHR11: 117857105 -117872199
Locus: 11q23.3
PHLDB1 Gene Summary
The Pleckstrin Homology Like Domain Family B Member 1 (PHLDB1) gene is located on chr11 :118477212-118528741 at 11q23.3.
Gene Name: Pleckstrin Homology Like Domain Family B Member 1
Chromosome: CHR11: 118477212 -118528741
Locus: 11q23.3
Gene Diseases
The PHLDB1 IL10RA Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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