PHF8-FAM120C Fusion FISH Probe
The PHF8-FAM120C Fusion FISH Probe is used to confirm a fusion of the PHF8 and FAM120C genes. The fusion of the PHF8 and FAM120C genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PHF8-FAM120C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-RERE | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-REOR | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-REGO | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-REGR | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-REAQ | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-ORRE | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-OROR | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-ORGO | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-ORAQ | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-GORE | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-GOOR | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-GOGO | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-GOGR | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-GOAQ | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-GRRE | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-GROR | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-GRGO | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-GRGR | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-GRAQ | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-AQRE | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-AQOR | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-AQGO | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-AQGR | 20 (40 μL) | 200 μL |
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| PHF8-FAM120C-20-AQAQ | 20 (40 μL) | 200 μL |
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PHF8 Gene Summary
The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. The protein has an N-terminal PHD finger and a central Jumonji C domain. This gene is thought to function as a transcription activator. Defects in this gene are a cause of syndromic X-linked Siderius type intellectual disability (MRXSSD) and over-expression of this gene is associated with several forms of cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
Gene Name: PHD Finger Protein 8
Chromosome: CHRX: 53963112 -54071569
Locus: Xp11.22
FAM120C Gene Summary
This gene encodes a potential transmembrane protein and lies in a region where mutations and deletions have been associated with intellectual disability and autism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Name: Family With Sequence Similarity 120C
Chromosome: CHRX: 54094756 -54209714
Locus: Xp11.22
Gene Diseases
The PHF8 FAM120C Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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