PHF21A-GLIS2 Fusion FISH Probe
The PHF21A-GLIS2 Fusion FISH Probe is used to confirm a fusion of the PHF21A and GLIS2 genes. The fusion of the PHF21A and GLIS2 genes has been associated with Acute Myeloid Leukemia, and Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PHF21A-GLIS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-RERE | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-REOR | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-REGO | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-REGR | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-REAQ | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-ORRE | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-OROR | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-ORGO | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-GORE | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-GOOR | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-GOGO | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-GOGR | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-GRRE | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-GROR | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-GRGO | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-GRGR | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-AQRE | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-AQOR | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-AQGO | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-AQGR | 20 (40 μL) | 200 μL |
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| PHF21A-GLIS2-20-AQAQ | 20 (40 μL) | 200 μL |
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PHF21A Gene Summary
The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010]
Gene Name: PHD Finger Protein 21A
Chromosome: CHR11: 45950869 -46142985
Locus: 11p11.2
GLIS2 Gene Summary
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.[provided by RefSeq, Jan 2010]
Gene Name: GLIS Family Zinc Finger 2
Chromosome: CHR16: 4382224 -4389598
Locus: 16p13.3
Gene Diseases
The PHF21A GLIS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Acute Myeloid Leukemia |
| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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