PHF21A-ALKBH3 Fusion FISH Probe
The PHF21A-ALKBH3 Fusion FISH Probe is used to confirm a fusion of the PHF21A and ALKBH3 genes. The fusion of the PHF21A and ALKBH3 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PHF21A-ALKBH3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-RERE | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-REOR | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-REGO | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-REGR | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-REAQ | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-ORRE | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-OROR | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-ORGO | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-ORAQ | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-GORE | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-GOOR | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-GOGO | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-GOGR | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-GOAQ | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-GRRE | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-GROR | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-GRGO | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-GRGR | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-GRAQ | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-AQRE | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-AQOR | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-AQGO | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-AQGR | 20 (40 μL) | 200 μL |
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| PHF21A-ALKBH3-20-AQAQ | 20 (40 μL) | 200 μL |
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PHF21A Gene Summary
The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010]
Gene Name: PHD Finger Protein 21A
Chromosome: CHR11: 45950869 -46142985
Locus: 11p11.2
ALKBH3 Gene Summary
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
Gene Name: AlkB Homolog 3, Alpha-ketoglutaratedependent Dioxygenase
Chromosome: CHR11: 43902356 -43941825
Locus: 11p11.2
Gene Diseases
The PHF21A ALKBH3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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