PHC2-NLRP4 Fusion FISH Probe
The PHC2-NLRP4 Fusion FISH Probe is used to confirm a fusion of the PHC2 and NLRP4 genes. The fusion of the PHC2 and NLRP4 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PHC2-NLRP4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-RERE | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-REOR | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-REGO | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-REGR | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-REAQ | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-ORRE | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-OROR | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-ORGO | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-ORAQ | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-GORE | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-GOOR | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-GOGO | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-GOGR | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-GOAQ | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-GRRE | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-GROR | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-GRGO | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-GRGR | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-GRAQ | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-AQRE | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-AQOR | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-AQGO | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-AQGR | 20 (40 μL) | 200 μL |
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| PHC2-NLRP4-20-AQAQ | 20 (40 μL) | 200 μL |
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PHC2 Gene Summary
In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Polyhomeotic Homolog 2
Chromosome: CHR1: 33789223 -33841194
Locus: 1p35.1
NLRP4 Gene Summary
The protein encoded by this gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). This gene product has a demonstrated role as a negative regulator of autophagy and type I interferon signaling pathways as a result of protein interactions with its NACHT domain. The PYD domain has also been shown to be important in the inhibition of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells). [provided by RefSeq, Dec 2016]
Gene Name: NLR Family Pyrin Domain Containing 4
Chromosome: CHR19: 56347943 -56393220
Locus: 19q13.43
Gene Diseases
The PHC2 NLRP4 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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