PGAP3-TOP2A Fusion FISH Probe
The PGAP3-TOP2A Fusion FISH Probe is used to confirm a fusion of the PGAP3 and TOP2A genes. The fusion of the PGAP3 and TOP2A genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PGAP3-TOP2A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-RERE | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-REOR | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-REGO | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-REGR | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-REAQ | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-ORRE | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-OROR | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-ORGO | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-ORAQ | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-GORE | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-GOOR | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-GOGO | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-GOGR | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-GOAQ | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-GRRE | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-GROR | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-GRGO | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-GRGR | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-GRAQ | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-AQRE | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-AQOR | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-AQGO | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-AQGR | 20 (40 μL) | 200 μL |
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| PGAP3-TOP2A-20-AQAQ | 20 (40 μL) | 200 μL |
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TOP2A Gene Summary
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
Gene Name: DNA Topoisomerase II Alpha
Chromosome: CHR17: 38544772 -38574202
Locus: 17q21.2
PGAP3 Gene Summary
This gene encodes a glycosylphosphatidylinositol (GPI)-specific phospholipase that primarily localizes to the Golgi apparatus. This ubiquitously expressed gene is predicted to encode a seven-transmembrane protein that removes unsaturated fatty acids from the sn-2 position of GPI. The remodeling of the constituent fatty acids on GPI is thought to be important for the proper association between GPI-anchored proteins and lipid rafts. The tethering of proteins to plasma membranes via posttranslational GPI-anchoring is thought to play a role in protein sorting and trafficking. Mutations in this gene cause an autosomal recessive form of neurologic hyperphosphatasia with cognitive disability (HPMRS4). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
Gene Name: Post-GPI Attachment To Proteins 3
Chromosome: CHR17: 37827374 -37844310
Locus: 17q12
Gene Diseases
The PGAP3 TOP2A Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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