PGAP3-LRRC6 Fusion FISH Probe
The PGAP3-LRRC6 Fusion FISH Probe is used to confirm a fusion of the PGAP3 and LRRC6 genes. The fusion of the PGAP3 and LRRC6 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PGAP3-LRRC6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-RERE | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-REOR | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-REGO | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-REGR | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-REAQ | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-ORRE | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-OROR | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-ORGO | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-ORAQ | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-GORE | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-GOOR | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-GOGO | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-GOGR | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-GOAQ | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-GRRE | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-GROR | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-GRGO | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-GRGR | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-GRAQ | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-AQRE | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-AQOR | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-AQGO | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-AQGR | 20 (40 μL) | 200 μL |
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| PGAP3-LRRC6-20-AQAQ | 20 (40 μL) | 200 μL |
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LRRC6 Gene Summary
The protein encoded by this gene contains several leucine-rich repeat domains and appears to be involved in the motility of cilia. Defects in this gene are a cause of primary ciliary dyskinesia-19 (CILD19). Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4, 11 and 22. [provided by RefSeq, Apr 2016]
Gene Name: Leucine Rich Repeat Containing 6
Chromosome: CHR8: 133584446 -133687813
Locus: 8q24.22
PGAP3 Gene Summary
This gene encodes a glycosylphosphatidylinositol (GPI)-specific phospholipase that primarily localizes to the Golgi apparatus. This ubiquitously expressed gene is predicted to encode a seven-transmembrane protein that removes unsaturated fatty acids from the sn-2 position of GPI. The remodeling of the constituent fatty acids on GPI is thought to be important for the proper association between GPI-anchored proteins and lipid rafts. The tethering of proteins to plasma membranes via posttranslational GPI-anchoring is thought to play a role in protein sorting and trafficking. Mutations in this gene cause an autosomal recessive form of neurologic hyperphosphatasia with cognitive disability (HPMRS4). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
Gene Name: Post-GPI Attachment To Proteins 3
Chromosome: CHR17: 37827374 -37844310
Locus: 17q12
Gene Diseases
The PGAP3 LRRC6 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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