PGAP3-GRB7 Fusion FISH Probe
The PGAP3-GRB7 Fusion FISH Probe is used to confirm a fusion of the PGAP3 and GRB7 genes. The fusion of the PGAP3 and GRB7 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PGAP3-GRB7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-RERE | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-REOR | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-REGO | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-REGR | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-REAQ | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-ORRE | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-OROR | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-ORGO | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-ORAQ | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-GORE | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-GOOR | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-GOGO | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-GOGR | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-GOAQ | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-GRRE | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-GROR | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-GRGO | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-GRGR | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-GRAQ | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-AQRE | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-AQOR | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-AQGO | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-AQGR | 20 (40 μL) | 200 μL |
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| PGAP3-GRB7-20-AQAQ | 20 (40 μL) | 200 μL |
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GRB7 Gene Summary
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Gene Name: Growth Factor Receptor Bound Protein 7
Chromosome: CHR17: 37894161 -37903538
Locus: 17q12
PGAP3 Gene Summary
This gene encodes a glycosylphosphatidylinositol (GPI)-specific phospholipase that primarily localizes to the Golgi apparatus. This ubiquitously expressed gene is predicted to encode a seven-transmembrane protein that removes unsaturated fatty acids from the sn-2 position of GPI. The remodeling of the constituent fatty acids on GPI is thought to be important for the proper association between GPI-anchored proteins and lipid rafts. The tethering of proteins to plasma membranes via posttranslational GPI-anchoring is thought to play a role in protein sorting and trafficking. Mutations in this gene cause an autosomal recessive form of neurologic hyperphosphatasia with cognitive disability (HPMRS4). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
Gene Name: Post-GPI Attachment To Proteins 3
Chromosome: CHR17: 37827374 -37844310
Locus: 17q12
Gene Diseases
The PGAP3 GRB7 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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