PGAP3-ERBB2 Fusion FISH Probe
The PGAP3-ERBB2 Fusion FISH Probe is used to confirm a fusion of the PGAP3 and ERBB2 genes. The fusion of the PGAP3 and ERBB2 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma, and Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PGAP3-ERBB2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-RERE | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-REOR | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-REGO | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-REGR | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-REAQ | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-ORRE | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-OROR | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-ORGO | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-GORE | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-GOOR | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-GOGO | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-GOGR | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-GRRE | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-GROR | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-GRGO | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-GRGR | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-AQRE | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-AQOR | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-AQGO | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-AQGR | 20 (40 μL) | 200 μL |
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| PGAP3-ERBB2-20-AQAQ | 20 (40 μL) | 200 μL |
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ERBB2 Gene Summary
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Gene Name: Erb-b2 Receptor Tyrosine Kinase 2
Chromosome: CHR17: 37844392 -37884915
Locus: 17q12
PGAP3 Gene Summary
This gene encodes a glycosylphosphatidylinositol (GPI)-specific phospholipase that primarily localizes to the Golgi apparatus. This ubiquitously expressed gene is predicted to encode a seven-transmembrane protein that removes unsaturated fatty acids from the sn-2 position of GPI. The remodeling of the constituent fatty acids on GPI is thought to be important for the proper association between GPI-anchored proteins and lipid rafts. The tethering of proteins to plasma membranes via posttranslational GPI-anchoring is thought to play a role in protein sorting and trafficking. Mutations in this gene cause an autosomal recessive form of neurologic hyperphosphatasia with cognitive disability (HPMRS4). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
Gene Name: Post-GPI Attachment To Proteins 3
Chromosome: CHR17: 37827374 -37844310
Locus: 17q12
Gene Diseases
The PGAP3 ERBB2 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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