PFKFB3-ZNF831 Fusion FISH Probe
The PFKFB3-ZNF831 Fusion FISH Probe is used to confirm a fusion of the PFKFB3 and ZNF831 genes. The fusion of the PFKFB3 and ZNF831 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PFKFB3-ZNF831-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-RERE | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-REOR | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-REGO | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-REGR | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-REAQ | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-ORRE | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-OROR | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-ORGO | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-ORAQ | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-GORE | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-GOOR | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-GOGO | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-GOGR | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-GOAQ | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-GRRE | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-GROR | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-GRGO | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-GRGR | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-GRAQ | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-AQRE | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-AQOR | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-AQGO | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-AQGR | 20 (40 μL) | 200 μL |
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| PFKFB3-ZNF831-20-AQAQ | 20 (40 μL) | 200 μL |
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PFKFB3 Gene Summary
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
Gene Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Chromosome: CHR10: 6186842 -6277507
Locus: 10p15.1
ZNF831 Gene Summary
The Zinc Finger Protein 831 (ZNF831) gene is located on chr20 :57766074-57834167 at 20q13.32.
Gene Name: Zinc Finger Protein 831
Chromosome: CHR20: 57766074 -57834167
Locus: 20q13.32
Gene Diseases
The PFKFB3 ZNF831 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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