PFKFB3-AKR1C1 Fusion FISH Probe
The PFKFB3-AKR1C1 Fusion FISH Probe is used to confirm a fusion of the PFKFB3 and AKR1C1 genes. The fusion of the PFKFB3 and AKR1C1 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PFKFB3-AKR1C1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-RERE | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-REOR | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-REGO | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-REGR | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-REAQ | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-ORRE | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-OROR | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-ORGO | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-GORE | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-GOOR | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-GOGO | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-GOGR | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-GRRE | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-GROR | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-GRGO | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-GRGR | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-AQRE | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-AQOR | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-AQGO | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-AQGR | 20 (40 μL) | 200 μL |
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| PFKFB3-AKR1C1-20-AQAQ | 20 (40 μL) | 200 μL |
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AKR1C1 Gene Summary
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]
Gene Name: Aldo-keto Reductase Family 1 Member C1
Chromosome: CHR10: 5005453 -5020158
Locus: 10p15.1
PFKFB3 Gene Summary
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
Gene Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Chromosome: CHR10: 6186842 -6277507
Locus: 10p15.1
Gene Diseases
The PFKFB3 AKR1C1 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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