PFKFB1-ALAS2 Fusion FISH Probe
The PFKFB1-ALAS2 Fusion FISH Probe is used to confirm a fusion of the PFKFB1 and ALAS2 genes. The fusion of the PFKFB1 and ALAS2 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PFKFB1-ALAS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-RERE | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-REOR | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-REGO | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-REGR | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-REAQ | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-ORRE | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-OROR | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-ORGO | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-GORE | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-GOOR | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-GOGO | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-GOGR | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-GRRE | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-GROR | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-GRGO | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-GRGR | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-AQRE | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-AQOR | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-AQGO | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-AQGR | 20 (40 μL) | 200 μL |
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| PFKFB1-ALAS2-20-AQAQ | 20 (40 μL) | 200 μL |
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ALAS2 Gene Summary
The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: 5'-aminolevulinate Synthase 2
Chromosome: CHRX: 55035487 -55057497
Locus: Xp11.21
PFKFB1 Gene Summary
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
Gene Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Chromosome: CHRX: 54959589 -55020511
Locus: Xp11.21
Gene Diseases
The PFKFB1 ALAS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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