PFDN1-DNMT3L Fusion FISH Probe
The PFDN1-DNMT3L Fusion FISH Probe is used to confirm a fusion of the PFDN1 and DNMT3L genes. The fusion of the PFDN1 and DNMT3L genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PFDN1-DNMT3L-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-RERE | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-REOR | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-REGO | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-REGR | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-REAQ | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-ORRE | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-OROR | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-ORGO | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-ORAQ | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-GORE | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-GOOR | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-GOGO | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-GOGR | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-GOAQ | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-GRRE | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-GROR | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-GRGO | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-GRGR | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-GRAQ | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-AQRE | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-AQOR | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-AQGO | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-AQGR | 20 (40 μL) | 200 μL |
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| PFDN1-DNMT3L-20-AQAQ | 20 (40 μL) | 200 μL |
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PFDN1 Gene Summary
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
Gene Name: Prefoldin Subunit 1
Chromosome: CHR5: 139624634 -139682689
Locus: 5q31.3
DNMT3L Gene Summary
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Gene Name: DNA Methyltransferase 3 Like
Chromosome: CHR21: 45666222 -45682099
Locus: 21q22.3
Gene Diseases
The PFDN1 DNMT3L Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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