PEX7-MED23 Fusion FISH Probe
The PEX7-MED23 Fusion FISH Probe is used to confirm a fusion of the PEX7 and MED23 genes. The fusion of the PEX7 and MED23 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PEX7-MED23-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-RERE | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-REOR | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-REGO | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-REGR | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-REAQ | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-ORRE | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-OROR | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-ORGO | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-ORAQ | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-GORE | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-GOOR | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-GOGO | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-GOGR | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-GOAQ | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-GRRE | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-GROR | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-GRGO | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-GRGR | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-GRAQ | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-AQRE | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-AQOR | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-AQGO | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-AQGR | 20 (40 μL) | 200 μL |
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| PEX7-MED23-20-AQAQ | 20 (40 μL) | 200 μL |
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PEX7 Gene Summary
This gene encodes the cytosolic receptor for the set of peroxisomal matrix enzymes targeted to the organelle by the peroxisome targeting signal 2 (PTS2). Defects in this gene cause peroxisome biogenesis disorders (PBDs), which are characterized by multiple defects in peroxisome function. There are at least 14 complementation groups for PBDs, with more than one phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene have been associated with PBD complementation group 11 (PBD-CG11) disorders, rhizomelic chondrodysplasia punctata type 1 (RCDP1), and Refsum disease (RD). [provided by RefSeq, Oct 2008]
Gene Name: Peroxisomal Biogenesis Factor 7
Chromosome: CHR6: 137143701 -137235072
Locus: 6q23.3
MED23 Gene Summary
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012]
Gene Name: Mediator Complex Subunit 23
Chromosome: CHR6: 131895105 -131949363
Locus: 6q23.2
Gene Diseases
The PEX7 MED23 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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