PEX5-PRB2 Fusion FISH Probe
The PEX5-PRB2 Fusion FISH Probe is used to confirm a fusion of the PEX5 and PRB2 genes. The fusion of the PEX5 and PRB2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PEX5-PRB2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-RERE | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-REOR | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-REGO | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-REGR | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-REAQ | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-ORRE | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-OROR | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-ORGO | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-GORE | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-GOOR | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-GOGO | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-GOGR | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-GRRE | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-GROR | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-GRGO | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-GRGR | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-AQRE | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-AQOR | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-AQGO | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-AQGR | 20 (40 μL) | 200 μL |
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| PEX5-PRB2-20-AQAQ | 20 (40 μL) | 200 μL |
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PEX5 Gene Summary
The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
Gene Name: Peroxisomal Biogenesis Factor 5
Chromosome: CHR12: 7341758 -7371169
Locus: 12p13.31
PRB2 Gene Summary
This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats, polymorphic cleavage sites and polymorphic stop codons have been identified. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Oct 2015]
Gene Name: Proline Rich Protein BstNI Subfamily 2
Chromosome: CHR12: 11544473 -11548498
Locus: 12p13.2
Gene Diseases
The PEX5 PRB2 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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