PEX14-PRG4 Fusion FISH Probe
The PEX14-PRG4 Fusion FISH Probe is used to confirm a fusion of the PEX14 and PRG4 genes. The fusion of the PEX14 and PRG4 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PEX14-PRG4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-RERE | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-REOR | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-REGO | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-REGR | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-REAQ | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-ORRE | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-OROR | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-ORGO | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-ORAQ | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-GORE | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-GOOR | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-GOGO | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-GOGR | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-GOAQ | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-GRRE | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-GROR | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-GRGO | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-GRGR | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-GRAQ | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-AQRE | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-AQOR | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-AQGO | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-AQGR | 20 (40 μL) | 200 μL |
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| PEX14-PRG4-20-AQAQ | 20 (40 μL) | 200 μL |
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PEX14 Gene Summary
This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome. [provided by RefSeq, Jul 2008]
Gene Name: Peroxisomal Biogenesis Factor 14
Chromosome: CHR1: 10535002 -10690815
Locus: 1p36.22
PRG4 Gene Summary
The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Gene Name: Proteoglycan 4
Chromosome: CHR1: 186265404 -186283688
Locus: 1q31.1
Gene Diseases
The PEX14 PRG4 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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