PER3-PGD Fusion FISH Probe
The PER3-PGD Fusion FISH Probe is used to confirm a fusion of the PER3 and PGD genes. The fusion of the PER3 and PGD genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PER3-PGD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-RERE | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-REOR | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-REGO | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-REGR | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-REAQ | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-ORRE | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-OROR | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-ORGO | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-ORAQ | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-GORE | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-GOOR | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-GOGO | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-GOGR | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-GOAQ | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-GRRE | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-GROR | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-GRGO | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-GRGR | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-GRAQ | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-AQRE | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-AQOR | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-AQGO | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-AQGR | 20 (40 μL) | 200 μL |
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| PER3-PGD-20-AQAQ | 20 (40 μL) | 200 μL |
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PGD Gene Summary
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
Gene Name: Phosphogluconate Dehydrogenase
Chromosome: CHR1: 10459084 -10480201
Locus: 1p36.22
PER3 Gene Summary
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]
Gene Name: Period Circadian Regulator 3
Chromosome: CHR1: 7844762 -7905237
Locus: 1p36.23
Gene Diseases
The PER3 PGD Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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