PENK-PLAT Fusion FISH Probe
The PENK-PLAT Fusion FISH Probe is used to confirm a fusion of the PENK and PLAT genes. The fusion of the PENK and PLAT genes has been associated with Pheochromocytoma And Paraganglioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PENK-PLAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-RERE | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-REOR | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-REGO | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-REGR | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-REAQ | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-ORRE | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-OROR | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-ORGO | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-GORE | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-GOOR | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-GOGO | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-GOGR | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-GRRE | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-GROR | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-GRGO | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-GRGR | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-AQRE | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-AQOR | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-AQGO | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-AQGR | 20 (40 μL) | 200 μL |
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| PENK-PLAT-20-AQAQ | 20 (40 μL) | 200 μL |
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PENK Gene Summary
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015]
Gene Name: Proenkephalin
Chromosome: CHR8: 57353512 -57359282
Locus: 8q12.1
PLAT Gene Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Plasminogen Activator, Tissue Type
Chromosome: CHR8: 42032235 -42065194
Locus: 8p11.21
Gene Diseases
The PENK PLAT Fusion has been associated with the following diseases:
| Disease Name |
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| Pheochromocytoma And Paraganglioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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