PEMT-SCUBE1 Fusion FISH Probe
The PEMT-SCUBE1 Fusion FISH Probe is used to confirm a fusion of the PEMT and SCUBE1 genes. The fusion of the PEMT and SCUBE1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PEMT-SCUBE1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-RERE | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-REOR | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-REGO | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-REGR | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-REAQ | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-ORRE | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-OROR | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-ORGO | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-GORE | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-GOOR | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-GOGO | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-GOGR | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-GRRE | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-GROR | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-GRGO | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-GRGR | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-AQRE | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-AQOR | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-AQGO | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-AQGR | 20 (40 μL) | 200 μL |
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| PEMT-SCUBE1-20-AQAQ | 20 (40 μL) | 200 μL |
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PEMT Gene Summary
Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]
Gene Name: Phosphatidylethanolamine N-methyltransferase
Chromosome: CHR17: 17408876 -17494994
Locus: 17p11.2
SCUBE1 Gene Summary
This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology. [provided by RefSeq, Oct 2011]
Gene Name: Signal Peptide, CUB Domain And EGF Like Domain Containing 1
Chromosome: CHR22: 43599228 -43739394
Locus: 22q13.2
Gene Diseases
The PEMT SCUBE1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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