PDZD2-COL27A1 Fusion FISH Probe
The PDZD2-COL27A1 Fusion FISH Probe is used to confirm a fusion of the PDZD2 and COL27A1 genes. The fusion of the PDZD2 and COL27A1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDZD2-COL27A1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-RERE | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-REOR | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-REGO | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-REGR | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-REAQ | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-ORRE | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-OROR | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-ORGO | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-GORE | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-GOOR | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-GOGO | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-GOGR | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-GRRE | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-GROR | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-GRGO | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-GRGR | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-AQRE | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-AQOR | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-AQGO | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-AQGR | 20 (40 μL) | 200 μL |
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| PDZD2-COL27A1-20-AQAQ | 20 (40 μL) | 200 μL |
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PDZD2 Gene Summary
The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. [provided by RefSeq, Dec 2015]
Gene Name: PDZ Domain Containing 2
Chromosome: CHR5: 31799030 -32111038
Locus: 5p13.3
COL27A1 Gene Summary
This gene encodes a member of the fibrillar collagen family, and plays a role during the calcification of cartilage and the transition of cartilage to bone. The encoded protein product is a preproprotein. It includes an N-terminal signal peptide, which is followed by an N-terminal propetide, mature peptide and a C-terminal propeptide. The N-terminal propeptide contains thrombospondin N-terminal-like and laminin G-like domains. The mature peptide is a major triple-helical region. The C-terminal propeptide, also known as COLFI domain, plays crucial roles in tissue growth and repair. Mutations in this gene cause Steel syndrome. Alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been determined. [provided by RefSeq, Sep 2014]
Gene Name: Collagen Type XXVII Alpha 1 Chain
Chromosome: CHR9: 116918230 -117072975
Locus: 9q32
Gene Diseases
The PDZD2 COL27A1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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