PDSS2-SMARCA4 Fusion FISH Probe
The PDSS2-SMARCA4 Fusion FISH Probe is used to confirm a fusion of the PDSS2 and SMARCA4 genes. The fusion of the PDSS2 and SMARCA4 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDSS2-SMARCA4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-RERE | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-REOR | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-REGO | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-REGR | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-REAQ | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-ORRE | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-OROR | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-ORGO | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-GORE | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-GOOR | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-GOGO | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-GOGR | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-GRRE | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-GROR | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-GRGO | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-GRGR | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-AQRE | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-AQOR | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-AQGO | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-AQGR | 20 (40 μL) | 200 μL |
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| PDSS2-SMARCA4-20-AQAQ | 20 (40 μL) | 200 μL |
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SMARCA4 Gene Summary
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Name: SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 4
Chromosome: CHR19: 11071597 -11172958
Locus: 19p13.2
PDSS2 Gene Summary
The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. Defects in this gene are a cause of coenzyme Q10 deficiency.[provided by RefSeq, Oct 2009]
Gene Name: Decaprenyl Diphosphate Synthase Subunit 2
Chromosome: CHR6: 107473760 -107780779
Locus: 6q21
Gene Diseases
The PDSS2 SMARCA4 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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