PDS5B-COL4A1 Fusion FISH Probe
The PDS5B-COL4A1 Fusion FISH Probe is used to confirm a fusion of the PDS5B and COL4A1 genes. The fusion of the PDS5B and COL4A1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDS5B-COL4A1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-RERE | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-REOR | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-REGO | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-REGR | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-REAQ | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-ORRE | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-OROR | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-ORGO | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-GORE | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-GOOR | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-GOGO | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-GOGR | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-GRRE | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-GROR | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-GRGO | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-GRGR | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-AQRE | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-AQOR | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-AQGO | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-AQGR | 20 (40 μL) | 200 μL |
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| PDS5B-COL4A1-20-AQAQ | 20 (40 μL) | 200 μL |
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COL4A1 Gene Summary
This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Gene Name: Collagen Type IV Alpha 1 Chain
Chromosome: CHR13: 110801309 -110959496
Locus: 13q34
PDS5B Gene Summary
This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015]
Gene Name: PDS5 Cohesin Associated Factor B
Chromosome: CHR13: 33160563 -33352158
Locus: 13q13.1
Gene Diseases
The PDS5B COL4A1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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